胡晓兰

 胡晓兰

  助理研究员

  邮箱：xiaolanhu@jnu.edu.cn

  联系方式：020-85221076（办公室电话）

  地址：广州市天河区黄埔大道西601号暨南大学大气楼 207室 

研究方向

     1.呼气代谢组分析方法研究及其在临床诊断、治疗监测中的应用；

     2.蛋白组学分析方法的研究及其在环境污染物毒理机制方面的应用。

科研经历

2023-09至今,暨南大学,环境与气候学院,助理研究员

2023-08至2023-09,暨南大学,质谱仪器与大气环境研究所, 助理研究员

2022-01至2023-07,澳门科技大学,博士后

2018-09至2021-07,澳门科技大学,博士

 代表性科研成果

（一）论文

1. Xing Chen¹, Xiaolan Hu¹, XieguangZhang¹, Hui Huang, Heng Meng, Jianming Yang, Chen Tao, Wei Zhang, Xue Li, Keda Zhang. Breath analysis: Harnessing its potential for non-volatile drug caffeine monitoring in human body.Microchemical Journal, 2024: 110130. (Co-first author)

2. Xiaolan Hu, Shilin Gong, Quan He, Jian-Lin Wu^*, and Na Li^*.Less is more: A new perspective for toxicity of emerging contaminants by structures, protein adducts and proteomics.TrAC Trends in Analytical Chemistry, 2023, 117289.

3. Xiaolan Hu, Jian-Lin Wu^*, Wen Miao, Fei Long, Hudan Pan, Tao Peng, Xiaojun Yao, and Na Li^*. Covalent Protein Modification: An Unignorable Factor for Bisphenol A-induced Hepatotoxicity. Environmental Science &Technology,2022, 56, 9536−9545.

4. Shilin Gong¹, Xiaolan Hu¹, Shengshuang Chen, Baoqing Sun, Jian-Lin Wu^*, Na Li^*. Dual roles of drug or its metabolite-protein conjugate (DMPC): cutting-edge strategy of drug discovery using shotgun proteomics.Medicinal Research Reviews, 2022,42:1704-1734. (Co-first author)

5. Xiaolan Hu¹, XiqingBian¹, Wan-Yi Gu, Baoqing Sun, Xiang Gao, Jian-Lin Wu^*, Na Li^*. Stand out from matrix: Ultra-sensitive LC-MS/MS method for determination of histamine in complex biological samples using derivatization and solid phase extraction. Talanta, 2021, 225, 122056.

6. Xiaolan Hu, Xi-Qing Bian, Xin Wu, Jian-Yong Li, Hui-Ming Hua, Yue-Hu Pei, Ai-Hong Han, Jiao Bai^*. Penioxalamine A, a novel prenylated spiro-oxindole alkaloid from Penicillium oxalicumTW01-1. Tetrahedron Letters, 2014, 55(29): 3864-3867.

7. Yue Zhuo, Yida Zhang, Meng Li, Haiying Wu, Shilin Gong, Xiaolan Hu, Yu Fu, Xinzi Shen, Baoqing Sun, Jian-Lin Wu, Na Li*. Drug Hepatotoxic Evaluation via Biomarker Quantification and Pathway Mapping of Large-Scale Chemical Proteomics. Food and Chemical Toxicology, 2021, 153, 112257.

8. Shilin Gong, Yue Zhuo, Shengshuang Chen, Xiaolan Hu, Xing-xing Fan, Jian-Lin Wu*, Na Li*. Quantification of Osimertinib and Metabolite-Protein Modification Reveals Its High Potency and Long Duration of Effects on Target Organs. Chemical research in toxicology, 2021, 34(11), 2309–2318.

9. Sajad Fakhri, Merve Tomas, Esra Capanoglu, Yaseen Hussain, Fatemeh Abbaszadeh, Baiyi Lu, Xiaolan Hu, Jian-Lin Wu, Liang Zou, Antonella Smeriglio, Jesus Simal-Gandara, Hui Cao, Jianbo Xiao*, Haroon Khan*. Antioxidant and anticancer potentials of edible flowers: where do we stand? Critical reviews in food science and nutrition, 2021,1–57.

10. Xiao-Cui Zhuang, Yong-Li Zhang, Gui-Lin Chen, Ye Liu, Xiaolan Hu, Na Li, Jian-Lin Wu, Ming-Quan Guo*. Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgiaugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS. Pharmaceuticals (Basel, Switzerland), 2021, 14(4), 313.

11. XiqingBian, Jiao Bai*, Xiaolan Hu, Xin Wu, Chunmei Xue, Aihong Han, GuangyueSu, Huiming Hua, Yuehu Pei. Penioxalicin, a novel 3-nor-2, 3-seco-labdane type diterpene from the fungus Penicillium oxalicumTW01-1. Tetrahedron letters, 2015, 56(35): 5013-5016.

12. Xiao-Lei Zhou, Jiu-Hong WU*, Jiao Bai, Xiaolan Hu, En-Zhen LI, Ning SHI, Yue-Hu PEI. A new aristolactam alkaloid from the stems of Dasymaschalontrichophorum. Chinese Journal of Natural Medicines, 2013, 11(1): 81-83.

（二）专利

1. 裴月湖，白皎，陈刚，胡晓兰。双四氢苯并吡喃酮二聚体类化合物在抗癌药物中的应用，发明专利，专利申请号： 201110332660.6

2. 李娜，伍建林，胡晓兰。一种筛选潜在共价药物的方法, 澳门科技大学，发明专利，202310372589.7.